Rhino trial9/4/2023 ![]() Dworkin RH, O’Connor AB, Audette J, et al. ![]() No significant difference in the number of Fos-LI cells was observed on the contralateral side. The number of Fos-LI cells decreases from −1.8 mm to −1.2 mm in the trigeminal nucleus of the CCI + saline AC IOP group and the CCI + attach lidocaine group. The CCI + lidocaine AC IOP group showed a decrease in the number of Fos-LI cells from −2.4 mm to −0.6 mm in the trigeminal nucleus. These findings suggest that the effect of CCI + lidocaine AC IOP group may be caused by active permeation of lidocaine into the facial skin and electrical stimulation of the trigeminal nucleus.ĭistribution of the expression of Fos-LI cells in the trigeminal nucleus. A significant decrease in the number of Fos-like immunoreactive (LI) cells was observed in the CCI + lidocaine AC IOP group compared with that in the CCI group. In the CCI + lidocaine AC IOP group, an elevated withdrawal threshold was observed after AC IOP, and the duration of efficacy was longer compared with that in the CCI + saline AC IOP and CCI + attached lidocaine groups. CCI model rats were divided into four groups, namely, rats that received general anesthesia for 60 min except AC IOP (CCI: n = 5), AC IOP with 0.9% physiological saline for 60 min (CCI + saline AC IOP: n = 5), AC IOP with 4% lidocaine hydrochloride for 60 min (CCI + lidocaine AC IOP: n = 5), and attachment of two electrodes soaked with 4% lidocaine hydrochloride to the facial skin for 60 min (CCI + attach lidocaine: n = 5). This study aimed to examine the effect of AC iontophoresis on rats with the chronic constriction injury (CCI) to the infraorbital nerve by animal experiments. Yoko Yamazaki, Masahiro Umino, Haruhisa Fukayama, Masahiko Shimada, Yoko Yamazaki, Masahiro Umino, Haruhisa Fukayama, Masahiko Shimada Abstract
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